Endocrine Abstracts

Persistent organic pollutants (POPs) are lipophilic chemicals that chronically accumulate in the body during lifetime from fetal life. Some POPs alter the endocrine metabolism and are considered as endocrine disrupting chemicals (EDCs). Human exposure to EDCs, even at low doses, raises some serious concerns for human health because they can participate in hormone-dependent cancer initiation and progression (prostate, breast, testis). These mostly non-metabolizable molecules ar...

Persistent organic pollutants (POPs) are environmental contaminants that interfere with normal hormonal homeostasis and act as endocrine disrupting compounds (EDC). These molecules can mimic hormone effects on metabolism. The links between metabolism and cancer are now well established. Metabolism generates reactive oxygen species (ROS), which contribute to mutations and induces oncogenic transformation. In turn, cancer cells display high metabolic flexibility allowing them to...

Endocrine disrupting chemicals (EDCs) produce adverse effects associated with numerous pathologies: neurological disorders, metabolic diseases, infertility and cancer for example. How EDCs interfere with the development of hormone-sensitive tissue is a major question in biology. In this study, we propose that the model of prostate organoids can be used to study the effects of EDCs on the development of the prostate gland. Indeed, the differentiation of adult stem cells (ASC) i...